Paul Saladino MD podcast podcast | Listen online for free (2024)

249. Bloodwork Review: April 2024

This week, Paul shares his most recent set of bloodwork in totality. He shares what he decides to order and why, and what bloodwork you may consider getting yourself. He also unpacks the importance of cortisol to DHEA sulphate radio and his cholesterol results.00:00:00 Podcast begins00:01:40 Traditional bloodwork00:05:40 MTHFR polymorphism: Does Paul take supplements?00:10:10 Glucose & creatine00:14:10 Electrolytes & insulin00:23:10 Thyroid panel00:26:18 Cortisol to DHEA sulphate ratio00:32:20 Cholesterol panel00:46:10 Hormones & Other results00:50:20 Iron panel00:52:40 What bloodwork should you get?References:July 2022 Bloodwork: https://www.youtube.com/watch?v=NuD9lWHMup8&t=669sAugust 2022 Bloodwork: https://www.youtube.com/watch?v=1br0cDkYv3YDecember 2022 Bloodwork: https://www.youtube.com/watch?v=LQE3mrwaE8cMarch 2023 Bloodwork: https://www.youtube.com/watch?v=vonHW14TTdgDEXA scan reveals “side effects” of red meat: https://www.youtube.com/shorts/ZgRoz60ugncCortisol, DHEA sulphate, their ratio, and all-cause and cause-specific mortality in the Vietnam Experience Study: https://pubmed.ncbi.nlm.nih.gov/20498139/Cholesterol, coconuts, and diet on Polynesian atolls: a natural experiment: the Pukapuka and Tokelau island studies: https://pubmed.ncbi.nlm.nih.gov/7270479/Cardiovascular risk factors in a Melanesian population apparently free from stroke and ischaemic heart disease: the Kitava study: https://pubmed.ncbi.nlm.nih.gov/8077891/The effect of HMG-CoA reductase inhibitors on cognition in patients with Alzheimer's dementia: a prospective withdrawal and rechallenge pilot study: https://pubmed.ncbi.nlm.nih.gov/22921881/Lipid profile of term infants on exclusive breastfeeding and mixed feeding: a comparative study: https://pubmed.ncbi.nlm.nih.gov/17327867/Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults: https://www.nature.com/articles/s41598-018-38461-yLow-Density Lipoprotein Cholesterol Is Predominantly Associated With Atherosclerotic Cardiovascular Disease Events in Patients With Evidence of Coronary Atherosclerosis: The Western Denmark Heart Registry: https://pubmed.ncbi.nlm.nih.gov/36621817/Get your bloodwork from ultalabs.com

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248. Why I Built a Food Company with Anthony Gustin

While the food industry continues to follow its convenience, profit, addiction business model Paul and Anthony explain the ethos behind and process of creating Lineage Provisions, a radically transparent food company determined to play their part in elevating and celebrating food quality. Check out Lineage Meat Sticks here: lineageprovisions.com/psmdyt*Produced by Mountain Valley Media00:00:00 Podcast begins00:03:00 The devaluation of food preparation in modern society00:09:00 how supply chain issues contribute to poor food quality 00:17:50 Why it’s so hard to raise pork and chicken on their ancestral diet00:28:47 Ads00:45:21 Why most “grass-finished” beef isn’t what you think it is01:05:09 Lineage Ad01:13:21 Paul’s beef with seafood01:21:20 Testing for PFAs01:25:17 What to expect from Lineage Provisions 01:28:45 Answering FAQs about Lineage Provision’s meat sticksBuy Lineage Beef Sticks: https://lineageprovisions.com/products/classic-meat-sticks

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247. Gary Brecka: Tap Water is Lowering Your IQ!

Paul has Human Biologist and founder of 10X Health Systems Gary Brecka on the podcast this week. As a previous life insurance adjuster, he talks about longevity through the lens of maintenance, being nutritionally optimal, and biohacking. They touch on adequate water filtration, all things genes & methylation, and food sourcing in the US.*Produced by ⁠Mountain Valley Media00:00:00 Podcast begins00:01:23 What is fluoride and is it harmful?00:07:30 How to filter your water00:09:00 Western medicine & longevity00:27:00 Food sourcing and big food00:30:50 Cyanocobalamin00:34:55 Folic acid00:42:00 Gathering objective & subjective data00:49:00 The importance of gene testing & methylation

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246. Some things I'm experimenting with lately...

On today’s podcast, Paul shares some new things he’s been experimenting with lately including eating more heart, supplementing with creatine, attempting to incorporate white rice as a carb source, and most excitingly, the launch of his new company: Lineage.*Produced by ⁠Mountain Valley Media00:00:00 The importance of heart & riboflavin00:08:30 Pauls new company: Lineage00:10:50 Thoughts on creatine00:19:10 Paul’s experience with white rice & potatoes00:24:45 Paul experimenting with supplements for methylationCheck out Lineage Meat Sticks: https://lineageprovisions.com/passwordReferences:Riboflavin lowers hom*ocysteine in individuals hom*ozygous for the MTHFR 677C-T polymorphism: https://pubmed.ncbi.nlm.nih.gov/16380544/

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245. Debunking Sugar Claims: What Dr. Lustig Got Wrong On The Huberman Lab Podcast

This week, Paul talks to Mike Fave, critical care RN, about all things sugar & fructose. They share their thoughts on a recent podcast with Andrew Huberman and Alex Lustig, and why they disagree with certain points made about insulin, fruit juice, and fructose.*Produced by ⁠Mountain Valley Media00:00:00 Podcast begins00:04:00 Mike’s background00:05:15 Diving into fructose00:13:00 Thoughts on honey and other carb sources00:27:30 Robert Lustig rebuttal: is fructose addictive?00:37:40 Fructose & fiber00:47:00 How fructose affects the mitochondria00:51:00 Clarifying hyperglycemia vs. a postprandial hyperglycemia00:56:17 Is insulin the bad guy?01:12:20 How insulin relates to diabetes, obesity, and insulin resistance01:23:30 Balancing protein, fat and carbohydrates01:30:00 Is fructose making us fat?01:46:00 Final thoughtsConnect with Mike:Mikefave.comhttps://m.youtube.com/@MikeFaveSimplifiedReferences:Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.xA Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/A High-Fat Meal, or Intraperitoneal Administration of a Fat Emulsion, Increases Extracellular Dopamine in the Nucleus Accumbens: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061790/A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents: https://journals.physiology.org/doi/full/10.1152/ajpendo.00165.2014?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.orgConsumption of Raw Orange, 100% Fresh Orange Juice, and Nectar- Sweetened Orange Juice—Effects on Blood Glucose and Insulin Levels on Healthy Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770506/The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227984/Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM: https://pubmed.ncbi.nlm.nih.gov/9216960/Glucagon and type 2 diabetes: the return of the alpha cell: https://pubmed.ncbi.nlm.nih.gov/25344790/Insulin, growth hormone and sport: https://pubmed.ncbi.nlm.nih.gov/11431133/Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Insulin Clearance, and Insulin Sensitivity in Healthy Glucose-Tolerant Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881846/Fructose metabolism in humans – what isotopic tracer studies tell us: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533803/Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1433856/Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.xToll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice: https://pubmed.ncbi.nlm.nih.gov/19637282/Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP2E1-Mediated Oxidative and Nitrative Stress: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783321/

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